RNAi therapeutics: Can siRNAs conquer SARS?
نویسندگان
چکیده
منابع مشابه
Optimal choice of functional and off-target effect-reduced siRNAs for RNAi therapeutics
INTRODUCTION Small interfering RNA (siRNA) represses a specific target gene that has a perfectly complementary sequence by a pathway referred to as RNA interference (RNAi). Researchers have successfully diverted this natural pathway to artificially knockdown intended genes. RNAi shows promise for therapeutic applications to human diseases (Castanotto and Rossi, 2009; Ketting, 2011). Over the pa...
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The therapeutic utility of siRNAs is limited by the requirement for complex formulations to deliver them to tissues. If potent single-stranded RNAs could be identified, they would provide a simpler path to pharmacological agents. Here, we describe single-stranded siRNAs (ss-siRNAs) that silence gene expression in animals absent lipid formulation. Effective ss-siRNAs were identified by iterative...
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RNAi-mediated gene inactivation has become a cornerstone of the present day gene function studies that are the foundation of mechanism and target based drug discovery and development, which could potentially shorten the otherwise long process of drug development. In particular, the coming of age of "RNAi drug" could provide new promising therapeutics bypassing traditional approaches. However, t...
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RNA interference (RNAi) represents a mechanism invented by nature to protect the genome. In the past few years the field has emerged at a surprisingly high pace. RNA interference (RNAi) has advanced from its basic discovery in lower organisms to becoming a powerful genetic tool and perhaps our single most promising bio therapeutic for a wide array of diseases. Numerous studies document RNAi eff...
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ژورنال
عنوان ژورنال: Gene Therapy
سال: 2005
ISSN: 0969-7128,1476-5462
DOI: 10.1038/sj.gt.3302682